US Senate Seats up in 2022 January 27, 2021 by Staff Ballotpedia.org – There are 34 U.S. Senate seats up for regular election in 2022—14 seats held by Democrats and 20 held by Republicans. This is Why Your Vote Counts Related posts: US House Seats up in 2022 Colorado Needs Dan Baer McBath, Lucy Terry McAuliffe for Virginia’s Governor